Prof. Noopur Raje (Massachusetts General Cancer Center and Harvard Medical School, USA) presented an overview on targeted immune stimulation therapies in multiple myeloma (MM) [1 . In this MEDtalk Fredrik Schjesvold, the founder and leader of Oslo Myeloma Center at Oslo University Hospital and K.G. In order to navigate this complex clinical landscape, guidelines such as the International Myeloma Working Group (IMWG) and Stratification for Myeloma and Risk-Adopted Therapy (mSMART) recognize patient risk classification as an important tool [5, 6]. In all cases, individual patient circumstances may dictate an alternative approach. MajesTEC-1 is an open-label, multicohort, phase 1/2 study evaluating teclistamab in patients (pts) with relapsed/ refractory multiple myeloma (RRMM) previously treated with 3 prior lines of therapy (LOT). 2017: Moreau et al. The European Hematology Association (EHA) and European Society for Medical Oncology (ESMO) guidelines committees have jointly issued consensus-based recommendations for the diagnosis, treatment, and follow-up of patients with multiple myeloma (MM). Session title: Myeloma and other monoclonal gammopathies - Clinical Background Daratumumab, an anti-CD38 monoclonal antibody, is approved for Multiple Myeloma (MM) treatment at an intravenous (IV) dosage of 16 mg/kg with high rates of infusion-related reactions (IRR; 45-56%), especially at the first infusion. Multiple myeloma: European Hematology Society- European Society for Medical Oncology (EHA-ESMO) Clinical Practice Guidelines for diagnosis, treatment and follow-up. NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines ): NCCN Guidelines focus on the diagnosis, workup and management of MM IMWG: The IMWG is an international society with the mission to provide scientifically validated consensus guidelines for the global multiple myeloma community ESMO and the European Haematology Association (EHA) - the professional organisation representing haematologists in Europe - have recently agreed to collaborate on the production of European guidelines for haematological malignancies. Accessed June 19, 2021. https://bit.ly/3ha90QK . Multiple myeloma is a cancer of plasma cells. EHA 2020 - Multiple Myeloma EHA 2020 - Multiple Myeloma. Multiple Myeloma (MM) is a malignant plasma cell (PC) neoplasm "that accounts for 1-1.8% of all cancers and is the second most common hematological malignancy" [11]. Light-chain multiple myeloma (LCMM) is a less frequent type of multiple myeloma (MM), with a more aggressive course and poorer prognosis. Multiple myeloma (MM) is highly heterogenous and dynamic in its genomic abnormalities. Go to full guideline Download audit template EHA-ESMO Guidelines for the Diagnosis, Treatment, and Follow-up of Multiple Myeloma - European Medical Journal Home Hematology EHA-ESMO Guidelines for the Diagnosis, Treatment, and Follow-up of EHA-ESMO Guidelines for the Diagnosis, Treatment, and Follow-up of Multiple Myeloma 27th July 2021 8 Mins Hematology Download PDF Citation Note: due to its size/complexity, the multiple myeloma page has been split into sub-pages: Induction (transplant eligible and ineligible) First-line consolidation and maintenance . Presented at: 2021 EHA Congress; June 9-17, 2021; Poster EP1008. General Disease State and Treatment Guidelines; Expert Insights: Faculty-submitted cases; Case Presentation, Polling Questions, and Discussion . XPOVIO (selinexor) [prescribing information]. Patients with multiple myeloma (MM) seem to be at increased risk for more severe COVID-19 infection and associated complications due to their immunocompromised state, the older age and comorbidities. Multiple myeloma: EHA-ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up; Older. At present, this complexity increases due to the wide variety of clinical situations found in MM patients before they reach the status of . Conclusion and Post-session Survey; Upcoming . The treatment landscape of multiple myeloma (MM) has evolved considerably in recent years with the introduction of novel agents. The EHA-ESMO guidelines consider the following tests obligatory for the diagnosis of multiple myeloma [ 135] : Blood count and smear Serum electrophoresis and immunofixation Serum FLC assay Serum. In the phase III MAIA trial, the monoclonal antibody daratumumab plus lenalidomide and dexamethasone reduced the risk of disease progression or death by 44% versus lenalidomide plus dexamethasone in patients with newly diagnosed multiple myeloma, according . If we follow the European guidelines since 2017 . 3 University Hospital of Salamanca, IBSAL, Cancer Research Center, Salamanca, Spain. Management of AL Amyloidosis. By: Julia Fiederlein Posted: Monday, June 14, 2021. Multiple myeloma: EHA-ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up MA Dimopoulos, P Moreau, E Terpos, MV Mateos, S Zweegman, G Cook, M Delforge, R Hjek, F Schjesvold, M Cavo, H Goldschmidt, T Facon, H Einsele, M Boccadoro, J San-Miguel, Pieter Sonneveld , U Mey 2 Department of Hematology, University Hospital Htel-Dieu, Nantes, France. Capturing a representative image of these alterations is essential in understanding the molecular pathogenesis and progression of the disease but was limited by single-site invasive bone marrow (BM) biopsy-based genomics studies. The function of plasma cells is to produce antibodies. ASH Guidelines are developed by leading clinical, methodological, and patient experts through a rigorous process to review evidence and write actionable recommendations. Dr. Francesca Gay is Associate Professor in the University of Torino, Department of Molecular Biotechnology and Health Sciences, and works as hematologist at the SSD Clinical trials in onco-ematology and multiple myeloma, Division of Hematology, Azienda Ospedaliero-Universitaria Citt della Salute e della Scienza di Torino, Italy. Post-induction ixazomib as maintenance therapy in patients newly diagnosed with multiple myeloma not treated with front-line stem-cell transplantation (TOURMALINE-MM4 trial) resulted . Guideline Haemato-oncology. Ann Oncol. Each webinar offers the opportunity for live real-time interaction between audience and experts. Multiple myeloma: EHA-ESMO clinical practice guidelines for diagnosis, treatment and follow-up [39] Published by: European Hematology Association; European Society for Medical Oncology. Dimopoulos et al. These EHA-ESMO Clinical Practice Guidelines provide key recommendations on the management of multiple myeloma 11 In 2022, it is estimated that more than 34,000 people will be diagnosed with multiple myeloma, and more than 12,000 people will die from the disease in the U.S. 12 While some people diagnosed with multiple myeloma initially have no symptoms, most patients . 2021;5:e528), additional copyright text was added to the reference citations for supplementary tables S2, S3, S4, S5, and S7. (International MM Working Group), IMS (International MM Society), EHA and ASH. 1 CAS PubMed . eha-esmo (2021) recommended that fit patients eligible for autologous stem cell transplant and aggressive therapy undergo induction therapy using vrd (bortezomib + lenalidomide + dexamethasone) or. Published: 09/10/2014. Dimopoulos MA, Moreau P, Terpos E, Mateos MV, Zweegman S, Cook G, et al. Multiple Myeloma: EHA-ESMO Clinical Practice Guidelines for Diagnosis, Treatment and Follow-up Hemasphere . Multiple Choice Questions . For patients with newly diagnosed or relapsed multiple myeloma, regardless of transplant status, daratumumab (Darzalex) plus cyclophosphamide, bortezomib, and dexamethasone (CyBorD) induction followed by daratumumab maintenance therapy achieved durable and deep responses, according to data from the LYRA trial (NCT02951819) presented at the 2021 European Hematology Association (EHA) Congress. Our state-of-the-art methodology ensures that they meet the highest standards for trustworthiness and transparency. The objective of this guideline is to provide healthcare professionals with clear guidance on the antimyeloma management of patients with newly diagnosed multiple myeloma. Multiple Myeloma patients with documented disease progression or refractory disease while on current treatment with any carfilzomib-containing regimen (arm 1), any pomalidomide-containing regimen (arm 2) or any daratumumab-containing regimen (exploratory arm) will be included in the study. Last published: 2021. What is multiple myeloma? Since the publication of the article entitled "Multiple Myeloma: EHA-ESMO Clinical Practice Guidelines for Diagnosis, Treatment and Follow-up" ( HemaSphere. First described in 1848, MM is characterized by a proliferation of malignant plasma cells and a subsequent overabundance of monoclonal paraprotein (M protein). Generally regimens that are intended for a long or indefinite duration would be considered maintenance, whereas regimens with a short intended course would be considered consolidation. Treat Follow- Hemasphere. Tonight, Dr. Brian Durie will discuss some important new findings from ASCO, which is the American Society of Clinical . Additional data will be presented at a future congress or published in a medical journal. Antibodies occur naturally in our immune system and help protect us from infections. This EHA-ESMO Clinical Practice Guideline provides key recommendations on the management of multiple myeloma Authorship includes a multidisciplinary group of experts from different institutions and countries in Europe Key treatment recommendations are provided for both newly diagnosed myeloma patients and patients with relapsed/refractory disease This EHA-ESMO Clinical Practice Guideline provides key recommendations on the management of multiple myeloma Authorship includes a multidisciplinary group of experts from different institutions and countries in Europe Key treatment recommendations are provided for both newly diagnosed myeloma patients and patients with relapsed/refractory disease About Multiple Myeloma Multiple myeloma is an incurable blood cancer that starts in the bone marrow and is characterized by an excessive proliferation of plasma cells. 2021;32(3) . . RARITAN, N.J., May 31, 2022 The Janssen Pharmaceutical Companies of Johnson & Johnson announced today that new research and data from its robust oncology portfolio and pipeline of investigational therapies will be presented at the 2022 American Society of Clinical Oncology (ASCO) Annual Meeting, taking place June 3-7 in Chicago, and the European Hematology Association (EHA) 2022 Congress . Jebsen Centre for B cell malignancie, University of Oslo presents the key recommendations on the management of multiple myeloma from the EHA-ESMO Clinical Practice Guideline. Welcome and Introduction, Prof. Francesca . Multiple myeloma: EHA-ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Design: U.S.-licensed oncologists and hematologists convened at a live . Pomalidomide, Cyclophosphamide, and Dexamethasone (POMCIDEX) in Relapsed/Refractory Multiple Myeloma . Ann Oncol . Patients with newly diagnosed MM (NDMM) who are not considered suitable candidates for high-dose chemotherapy and autologous stem cell transplantation because of age or comorbidities are currently treated with combination therapies including steroids, alkylators, and . 2021;5:e528), the EHA Executive Office and ESMO Guidelines Committee would like to inform the readership of corrections to the manuscript section entitled "Treatment of relapsed . Dr. Mara-Victoria Mateos discusses Highlights in Multiple Myeloma . The two societies nominated authors to write the guidelines as well as reviewers to comment on them. In this MEDtalk Fredrik Schjesvold, the founder and leader of Oslo Myeloma Center at Oslo University Hospital and K.G. Results from the Phase 3 BELLINI trial evaluating patients with relapsed/refractory multiple myeloma were presented at the 24th European Hematology Association (EHA) Annual Congress during the late-breaking oral presentation session on Sunday, June 16. Clinical guidelines on the management of multiple myeloma (MM) were published in February 2021 by the European Hematology Association and the European Society for Medical Oncology in HemaSphere. In 2020, an estimated 176,000 people worldwide were diagnosed with multiple myeloma. NCCN Guidelines - Multiple Myeloma Consolidation after first-line therapy Note that there is no crisp distinction between consolidation and maintenance. Welcome everyone, and thank you for joining us for the International Myeloma Foundation's Best of ASCO and EHA 2022 Webinar, What Patients and Care Partners Need to Know. : Multiple myeloma: ESMO Clinical Practice Guidelines for diagnosis, treatment and . However, it remains a complex and expensive technology, which poses challenges to health-care systems and society in general, especially in times of crises. NCCN Clinical Practice Guidelines in Oncology. As a result, scientists are planning to evaluate belantamab mafodotin in combination with an anti-OX40 agonist in the upcoming DREAMM-5 clinical trial. Recommendations for acquisition, interpretation and reporting of whole body low dose CT in patients with multiple myeloma and other plasma cell disorders: a report of . Multiple myeloma: ESMO . She completed her medical degree in 2004 and her Continued Affiliations. Yet, their role and adoption in the real world remains limited. Multiple myeloma: EHA-ESMO clinical practice guidelines for diagnosis. Chimeric antigen receptor (CAR) T-cell therapy is a promising immunotherapeutic approach in the treatment of multiple myeloma, and the recent approval of the first two CAR T-cell products could result in improved outcomes. The late-breaking oral session at the 2022 European Hematology Association (EHA) Congress allowed investigators to present recently emerging data from abstracts submitted after the deadline . This webinar series of ESMO Guidelines: Real World Cases brings together all the relevant stakeholders who are developing each guideline, as well as those who are consulting and implementing the guideline. 5 In 2022, it is estimated that more than 34,000 . The increase in the number of therapeutic alternatives for both newly diagnosed and relapsed/refractory multiple myeloma (RRMM) patients has widened the clinical scenario, leading to a level of complexity that no algorithm has been able to cover up to date. The 2 societies nominated authors to write the guidelines as well as reviewers to comment on them. These Guidelines were developed by the European Hematology Association (EHA) and European Society for . 1 The second was organized by the European Hematology Association (EHA) and European Society for Blood and Marrow Transplantation (EBMT) and was entitled 'COVID-19 and hematology patient . ASH Clinical Practice Guidelines. Multiple myeloma: EHA-ESMO Clinical Practice Guidelines for diagnosis, . These adjustments have been made within the Supplementary . The group closely collaborates with the European Myeloma Network (EMN) and the patient organizations Myeloma Euronet and the European Myeloma Platform. Among her invited presentations, she has contributed to the educational sessions of EHA 2012, ASH 2013, ASCO 2015, EHA 2016, ASCO and ASH 2017. . The first-in-human study with belantamab mafodotin (DREAMM-1; BMA117159; NCT02064387) in patients with relapsed/refractory multiple myeloma was an open-label, 2-part Phase . Further details. Jebsen Centre for B cell malignancie, University of Oslo present the key recommendations on the management of multiple myeloma from the EHA-ESMO Clinical Practice Guideline. These are a type of white blood cells which originate in the bone marrow. 2021;32(3):309-322. Karyopharm Therapeutics Inc; Approved 2019. This potentially . Making Sense of Myeloma Treatment. Multiple Myeloma: EHA-ESMO Clinical Practice Guidelines for Diagnosis, Treatment and Follow-up Meletios A. Dimopoulos, Philippe Moreau, Evangelos Terpos, Mara Victoria Mateos, Sonja Zweegman , Gordon Cook, Michel Delforge, Roman Hjek, Fredrik Schjesvold, Michele Cavo, Hartmut Goldschmidt, Thierry Facon, Hermann Einsele, Mario Boccadoro . . multiple myeloma is a malignant clonal bone marrow plasma cell tumor with excessive monoclonal protein production leading to bone destruction and . Multiple myeloma: EHA-ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-upy M. A. Dimopoulos1, P. Moreau2, . doi: 10.1097/HS9.0000000000000528. For patients with newly diagnosed or relapsed multiple myeloma, regardless of transplant status, daratumumab (Darzalex) plus cyclophosphamide, bortezomib, and dexamethasone (CyBorD) induction . Multiple myeloma, version 7.2021. Dimopoulos MA, Moreau P, Terpos E, et al; EHA Guidelines Committee; ESMO Guidelines Committee. Several recent clinical trials for immuno- and cellular therapies in myeloma have shown promising efficacy and safety results, paving the way for increased efficacy by combining or sequencing novel therapies. 2021;5:e528. Objective: Evaluate trends in self-reported perceptions and utilization of MRD in routine clinical care of multiple myeloma (MM) patients. Risk classification provides information based on disease biology to report on prognosis that . 2021 Feb 3;5(2):e528. Multiple Myeloma | Bio Ascend is an independent medical education company committed to supporting oncology and hematology healthcare providers . EHA 2020 - Multiple Myeloma Comparison of MRD Status by 3 Techniques in Newly Diagnosed Transplant-Eligible MM Patients In newly diagnosed transplant-eligible multiple myeloma patients who achieved very good partial response or better in the Italian FORTE study, there was strong concordance among 3 minimal residual disease-assessing techniques. Survival of multiple myeloma (MM) has significantly improved over the past decade; however, a composed group of patients (15% to 20%), named high-risk (HR) MM, still experiences reduced survival. Oral selinexor, pomalidomide, and dexamethasone (XPD) at recommended phase 2 dose in relapsed/refractory multiple myeloma (MM). Multiple myeloma: EHA-ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. We compared the mutational landscapes of circulating tumor DNA (ctDNA) and BM . First in human trial. 2021 . The SWG on Multiple Myeloma supports a range of clinical trials and biological research, which are presented at several international meetings and disseminated through international journals. INTRODUCTION. Pomalidomide, Cyclophosphamide, and Dexamethasone (POMCIDEX) in Relapsed/Refractory Multiple Myeloma . Multiple Myeloma: EHA-ESMO Clinical Practice Guidelines for Diagnosis, Treatment, and Follow-up These Guidelines were developed by the European Hematology Association (EHA) and European Society for Medical Oncology (ESMO). Context: Minimal residual disease (MRD) platforms carry prognostic and predictive value in hematologic malignancies. Both tumor biology and suboptimal/absent responses to therapy may underlie HR definition and a clear uniform identification of risk factors . 2 Post-induction ixazomib as maintenance therapy in patients newly diagnosed with multiple myeloma not treated with front-line stem-cell transplantation (TOURMALINE-MM4 trial) resulted . At the IMWG Conference Series, "Making Sense of Treatment," leading myeloma experts discussed the latest drug therapy news from the June 2022 American Society of Clinical Oncology (ASCO) Annual Conference, IMF IMWG Summit, and the European Hematology Association (EHA) Annual Conference. 2. White D, Chen C, Baljevic M, et al. [. Moreau P, San Miguel J, Sonneveld P, et al. EHA2021: MAIA Trial Update on Daratumumab-Based Therapy for Newly Diagnosed Myeloma . Multiple myeloma is an incurable blood cancer that starts in the bone marrow and is characterized by an excessive proliferation of plasma cells. BSH-EHA Joint Membership Membership FAQs Event Proposal Membership Survey 2020 . Moulopoulos LA, Koutoulidis V, Hillengass J, et al. These Guidelines were developed by the European Hematology Association (EHA) and ESMO. EHA 2020 - Multiple Myeloma EHA 2020 - Multiple Myeloma. M. Boccadoro14, J. San-Miguel15, P. Sonneveld16 & U. Mey17, on behalf of the EHA Guidelines Committee* and ESMO Guidelines Committee* 1Department of Clinical Therapeutics, School of Medicine, National and . Since the publication of the article entitled "Multiple Myeloma: EHA-ESMO Clinical Practice Guidelines for Diagnosis, Treatment and Follow-up" ( HemaSphere. Multiple Myeloma: EHA-ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up - Supplementary Material MANAGEMENT OF FRAIL ELDERLY PATIENTS It is important to realise that one third of patients are >75 years at diagnosis and at least 30% are frail, as defined by the International Myeloma Working Group Frailty Index (IMWG-FI). I'm Robin Tuohy, Vice President, Support Groups. These guidelines comprise comprehensive recommendations covering diagnosis, staging and risk assessment, treatment and . et al. These were published in the February 2021 edition of HemaSphere.1 5 In 2022, it is estimated . In January 2017, the European Society of Medical Oncology (ESMO) issued an update of their Clinical Practice Guidelines for Multiple Myeloma (MM), which was published in the March edition of Annals of Oncology.This document built on the previous draft published in 2013. 4 Department of Hematology, Amsterdam UMC . This document (115 pages excluding references, 50 tables, and 48 figures) is the result of an immense undertaking by the European Society of Cardiology (ESC), European Hematology Association, European Society for Therapeutic Radiology and Oncology, and International Cardio-Oncology Society in producing guidelines covering all aspects of the practice of cardio-oncologythe cardiovascular care .
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