MetaCyc: Chemical Formula: C 15 H 21 N 5 O 15 P 2: Molecular Weight: 573.3 Daltons: Monoisotopic Mass: 577.08223818 Daltons: Report Errors or Provide Feedback Page generated by Pathway Tools version 26.0 (software . For the first time, AICAR was used in the year 1980 as a drug to prevent the blood flow to the cardiac region during the surgery process. There is ongoing research into the use of AICAR to mediate the effects of diabetes, auto-immune diseases, and other inflammatory conditions. 2D chemical structure image of ab120358, AICAR (Acadesine/AICA riboside), AMPK activator. 17513. Aicar Nasal Spray 23.39 - 41.39 Laboratory research studies have shown the Aicar peptide vial to have the following benefits: Increase the efficiency of energy conversion Increased capacity for adipose tissue breakdown High ability to burn fat efficiently Maintain stability during a cardiac ischemic episode Molecular Formula: C9H15N4O8P Molecular Weight: 338.21 g/mol Purity: 99% . AMPK activator Shop AICAR, Tocris Bioscience at Fishersci.com. AMPK regulates lipid and glucose metabolism to maintain cellular energy homeostasis (Hardie and Carling). Here we aim to determine whether the therapeutic effects of AICAR against insulin resistance involve its anti-inflammatory function, which requires macrophage SIRT1. Appearance: Sterile filtered white lyophilized (freeze-dried) powder. Molecular Weight: 258.2: Purity: 99%: Validation: Exhibits correct molecular weight: Solubility: Soluble in water (10 mg/ml). Functional Studies - AICAR (Acadesine/AICA riboside), AMPK activator (ab120358) . Target. Molecular weight. . Dollar Store View . To elicit a maximal insulin response, mice were injected intraperitoneally with 1 unit of recombinant human insulin (humulin R, #HI 210, Lilly). AICAR (AICA ribonucleotide) 50mg Peptide Vial Australia. KPV Peptide. . Monoisotopic Mass. The mean AICAR value for all samples was 2,186 ng/mL with a standard deviation of 1,655 ng/mL. Heating to 37C and/or additional vortexing may be required. AICAR 15ml Contains: 50mg. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions. It provides protection against acute tubular necrosis. 258.23. Storage instructions. Fisher Scientific ; Fisher Healthcare ; Fisher Science Education ; Sign Up for Email . AICAR (Acadesine) Bodybuilding Application. Molecular Weight: 258.23. AICAR (Acadesine) is an adenosine analog and a AMPK activator. PubChem identifier. . National Institutes of Health. AICAR-dependent preconditioning is also mediated by an ATP-sensitive potassium channel and hemeoxygenase-dependent mechanism. Application, Sequence: 5-amino-4-imidazole carboxamide ribotide. Reviews . AICAR: Description: AICAR, also known as Z-nucleotide or ZMP, belongs to the class of organic compounds known as 1-ribosyl-imidazolecarboxamides. the time courses of aicar-stimulated akt substrate phosphorylation at a molecular weight of 160 (pas-160) and ampk thr-172 phosphorylation ( p-ampk) in vivo were determined by injecting mice with aicar subcutaneously for 0 (control), 10, 30, or 60 min. . Reviews There are no reviews yet. Molecular Formula: C9H14N4O5: Molecular Weight (g/mol) 258.23: MDL Number: MFCD00869751: InChI Key: RTRQQBHATOEIAF-UUOKFMHZSA-N: Synonym: HMW adiponectin dose . [1] , AICAR's interacts directly with AMPK, inducing a conformational change that favors phosphorylation of the catalytic alpha subunit. Description AICAR is a cell-permeable adenosine analog that is a selective activator of AMP-activated protein kinase (AMPK) in adipocytes and hepatocytes. Purine precursor that has antineoplastic activity. Molecular formula. AMPK is also a molecular target of 5-aminoimidazole-4-carboxamide-1--D-ribofuranoside (AICAR), which has been shown to reduce insulin resistance in various animal models. Molecular Formula: C 9 H 14 N 4 O 5: Molecular Weight AICAR is a cell-permeable, allosteric activator of AMP-activated protein kinase (AMPK). FANCD2 is involved in the regulation of . *The above data is based on the productmolecular weight 258.2 . It enhances the rate of nucleotide re . Solid form is stable at least 12 months from date of receipt, when stored as directed. Molecular Weight: 258.23 : Chemical structure: Molecular Formula: C 9 H 14 N 4 O 5: CAS Number: 2627-69-2 : PubChem identifier: 17513 : SMILES: O[C@@H]1[C@@H](CO)O[C@@H](N2C=NC(C(N)=O . Molecular Formula: C9H15N4O8P: Sequence: 5-aminoimidazole-4-carboxamide ribonucleoside: Molecular Weight: 338.213 g/mol: Elixir Labs Co Highest Quality Peptides And More. Molecular Weight: 258.23 EC Number: 220-097-5 MDL Number: MFCD00869751 Linear Formula: C 9 H 14 N 4 O 5 Product Type: Chemical. AICAR (commonly under the name Acadesine) is an analog of adenosine. 258.2 Da. Order AICAR (CAS 2627-69-2), a Autophagy inducer for your research. AICAR is also an autophagy, YAP and mitophagy inhibitor. . Phosphoribulosylformimino-AICAR-P: Description: Phosphoribulosylformimino-aicar-p is a member of the chemical class known as 1-Phosphoribosyl-imidazolecarboxamides. Although effective in reducing psychoses, OLZ causes acute increases in blood glucose. . . Pathway. AICAR is supplied as a lyphophilized powder. It enters cardiac cells to inhibit adenosine kinase and adenosine deaminase. View More View Less AICAR is a natural metabolic intermediate of the purine biosynthetic pathway. For a 75mM stock, reconstitute the 25 mg in 1.29 ml sterile diH20. FANCD2 is mapped to chromosome 3p25.3, has a theoretical molecular weight of 166 kDa and is localized in the nucleus. Biological Strategies: Western Blot: FANCD2 Antibody [NB100-182] - AMPK-activating AICAR treatment activates FANCD2, a pivotal molecule of Fanconi anemia DNA damage signaling pathway. EINECS: 220-097-5. Molecular Weight. Read more about Aicar on Wikipedia. Please contact us. Add to cart. AICAR (0.5 mM) inhibits insulin-stimulated glucose uptake to 62% of control cells and reduces GLUT4 translocation by 2.5-fold in 3T3-L1 adipocytes. MetaCyc. Read more about Aicar on Wikipedia. AICAR 50mg or referred to as 5-Aminoimidazole-4-carboxamide ribonucleotide. Chemical Structure - AICAR . Augments proliferation, differentiation and mineralization of osteoblastic MC3T3-EI cells and attenuates psychosine-induced expression of proinflammatory cytokines and iNOS in astrocytes. Aicar | C9H14N4O5 | CID 266934 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. Molecular mechanisms behind AICAr drug; impact on ALL. Purity >99%. AICAR 25ml Contains: 100mg. The AMPK is a metabolic regulator that inhibits anabolic processes and is active when energy availability is red Preparing Stock Solutions for AICAR, The following data is based on the product molecular weight 258.23. Immortalized human HSC line hTERT and primary rat HSCs were stimulated with platelet-derived growth factor (PDGF) with or without pretreatment with AMPK activator 5-aminoimidazole-4-carboxamide-1-4-ribofuranoside (AICAR), metformin, or high molecular weight (HMW) adiponectin. Store In the Dark. The AICAR peptide is a cell penetrable activator of AMPK (AMP-activated protein kinase) [1]. AICAR is an adenosine analog that selectively activates AMP-activated protein kinase (AMPK). . DNA synthesis was assessed via [3H]thymidine incorporation assay. It has a molecular mass of 338.211, and it has a molecular formula of C9H15N4O8P. (PDGF) with or without pretreatment with AMPK activator 5-aminoimidazole-4-carboxamide-1-4-ribofuranoside (AICAR), metformin, or high molecular weight (HMW) adiponectin. Average Molecular Weight: 577.331: Monoisotopic Molecular Weight . AICAR Chemical Structure, CAS No. Name: N1-(-D-Ribofuranosyl)-5-aminoimidazole-4-carboxamide S No. The method was fully validated for quantitative purposes considering the parameters linearity, inter- (12%, 7% . We do not sell to patients. Molecular formula. AICAR is a cell permeable activator of AMP-activated protein kinase (AMPK), a metabolic master regulator that is activated in . Product Citations (0) Currently there are no citations for this product. C 15 H 21 N 5 O 15 P 2. 573.3 Daltons. C 9 H 14 N 4 O 5. Add to Cart: Catalog Number PKG Qty. AICAr (5-amino-4-imidazolecarboxamide riboside, also called Acadesine) has been found to inhibit cell proliferation and has cytotoxic . incubation with ( ) or without ( ) AICAR or metformin for 2 hours, serum-starved hTERT HSCs were then stimulated with ( ) or without ( ) PDGF for 24 hours. [AICAR] .We manufacture and distribute chemical reagents for research use only or various antibodies. Appearance: Sterile filtered white lyophilized (freeze-dried) powder. Classification Codes Antiviral (COVID-19) Hypoglycemic Agents Molecular Formula C9-H15-N4-O8-P Molecular Weight 338.2115 All Links to Resources Names & Synonyms Registry Numbers Structure Descriptors Physical Properties Links to Resources NLM Resources (File Locators) DrugPortal MeSH PubChem PubMed AA Sequence: 5-Aminoimidazole-4-carboxamide ribonucleotide. Molecular Weight. pas-160 and p-ampk were measured in soleus ( a) and tibialis anterior muscle ( b) lysates by Promotes ligand-independent activation of the insulin receptor. : 2627-69-2, Molecular Weight: 338.21 g/mol. Aicar is an adenosine analog that selectively activates AMP-activated protein kinase (AMPK). Promotes osteogenic differentiation of hAMSCs and BM-MSCs in vitro . Various studies have been conducted on the potential uses and benefits of AICAR. The drug has also been shown as a potential treatment for diabetes by increasing the metabolic activity of tissues by changing the physical composition of muscle. For the treatment of cardiovascular diseases . These are organic compounds containing the imidazole ring linked to a ribose ring through a 1-2 bond. AMPK. Molecular Formula: C9H14N4O5. Aicar CAS:2627-69-2 Aicar Molecular Formula:C9H14N4O5 Aicar Molecular weight:258.23 Aicar Apperance:Off-White Powder Assay:99%min Usage:Pharmaceutical intermediates. AICAR is being researched to treat and protect against cardiac ischemic injury. . Availability: In stock, $60.00, Buy 3 for $58.00 each and save 4%, Buy 5 for $56.00 each and save 7%, The following have been the most revolutionary: Anti-aging effects: Mitochondria are considered the powerhouse of the body. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare . [AICAR] .We manufacture and distribute chemical reagents for research use only or various antibodies. It regulates lipid and glucose metabolism, pro-inflammatory responses, cytokine production, cell proliferation and apoptosis. Molecular weight. BUY Aicar Pre Mixed Peptide Online | Direct Sarms Iceland AICA RIBONUCLEOTIDE (AICAR) Pre Mixed Peptide 50mg 25.99 - 73.99 Laboratory research studies have shown the Aicar peptide vial to have the following benefits: Increase the efficiency of energy conversion Increased capacity for adipose tissue breakdown High ability to burn fat efficiently Molecular Formula: C9H15N4O8P: Molecular Weight: 338.2115: Optical Activity: UNSPECIFIED Defined Stereocenters: 4 / 4: E/Z Centers: 0: Charge: 0: . For research use only. AICAR, also known as acadesine, is an adenosine regulating agent and AMPK activator. PubChem . Molecular Weight: 338.211. AMPK. 10% off Sale. Download the HPLC Analysis/Mass Spectrum. 5 Cell permeable. Working concentrations and length of treatment can vary depending on the desired effect, but it is typically used at 0.5-2mM for 30 minutes-24 hours. Molecular Formula: C 9 H 15 N 4 O 8 P Molecular Weight: 338.21 g/mol Sequence: 5-amino-4-imidazole carboxamide ribotide aminoimidazole carboxamide ribonucleotide. AICAR is a cell-permeable, allosteric activator of AMP-activated protein kinase (AMPK). AMPK regulates lipid and glucose metabolism to maintain cellular energy homeostasis (Hardie and Carling). weight: 258.23 Molecular formula: C 9 H 14 N 4 O 5 Synonyms: Acadesine, Acadra Purity: >98% Form: raw powder CERTIFICATE OF ANALYSIS Articles of Acadesine are included as well. AICAR (0.5 mM) i. Molecular Formula: C9H15N4O8P: Molecular Weight: 338.211: Appearance: Sterile filtered white lyophilized (freeze-dried) powder: AA Sequence: Molecular Formula: C9H14N4O5. AICAR is an activator of AMP-activated protein kinase (AMPK). it's an important pharmacological research agent, used principally as an AMPK activator. This product is intended for research and medical purposes only, to be only used by trained professionals. 5AMP-activated protein kinase (AMPK) is an energy sensor activated . Molecular Formula: C 9H 14N 4O 5 Molecular Weight: 258.2 CAS Number: 2627-69-2 Purity: 98% Applications: FA Formulation: Crystalline solid Storage: Product should be kept at -20C. 12-to 15-month-old male baseline plasma lipid or blood glucose and echocardiographic measurements were performed 1 day before AICAR [500 mg/kg body weight] in saline was IP injected. Concentrations were found to differ depending on gender, type of sport and type of sample collection (in competition/out of competition). Be the first to review . . Item: AICAR Research. 2012 Jul 23;13(11):1628-34. doi: 10.1002/cbic.201200279. MOLECULAR WEIGHT: 338.213 g/mol. Aicar (Acadesine) Specifications: COA. AICAR is an AMP (adenosine monophosphate) analog that can effectively stimulate the AMPK (AMP-dependent protein kinase) activity. . [1] Contents, 1 Mechanism of action, AICAR or referred to as 5-Aminoimidazole-4-carboxamide ribonucleotide. AMPK is also a molecular target of 5-aminoimidazole-4-carboxamide-1--D-ribofuranoside (AICAR), . Augments proliferation, differentiation and mineralization of osteoblastic MC3T3-EI cells and attenuates psychosine-induced expression of proinflammatory cytokines and iNOS in astrocytes. 6-week-old male C57BL/6J (B6) mice were placed on either low fat (LF) or high fat (HF) diets for 24 weeks to establish a control or a DIO . In its monophosphate form, AICAR is a potent AMPK agonist, which at low concentrations, does not affect AMP, ADP, or ATP levels. The acute effects of OLZ on hyperglycemia are likely caused by reductions in insulin secretion, insulin resistance, and increased hepatic glucose production. AICAR Specifications. {15379} It increases AMPK kinase activity in isolated hepatocytes (EC50 = ~500 M) and reduces HMG-CoA reductase activity and fatty acid and sterol synthesis in these cells. Size. CAS: 2627-69-2. PubChem identifier. AICAR is a cell-permeable, allosteric activator of AMP-activated protein kinase (AMPK). . Promotes osteogenic differentiation of hAMSCs and BM-MSCs in vitro. Molecular Weight: 338.21 g/mol. Low dose AICAR does not change body weight and fat pad mass in established diet-induced obese (DIO) mice. 258.23. The AMPK is a metabolic regulator that inhibits anabolic processes and is active when energy availability is reduced. AICAR has antioxidant properties and may therefore help to slow the physiologic signs of aging. Store at or below -20C. Buy Aicar from Elixir Labs Co. 50mg Vial. SKU AICA (ribonucleotide) Nasal Spray Categories Nasal Sprays, AICAR, New Arrivals. 98%. Molecular Weight Peptides, Cyclic / chemical synthesis Peptides, Cyclic / chemistry . Purity: >99% (TLC); NMR (Conforms). 653 in stock. phosphoribulosylformimino-AICAR-phosphate . C 9 H 14 N 4 O 5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions. Molecular Weight: 258.2 g/mol. Molecular Formula: C 9 H 14 N 4 O 5: Molecular Weight Storage: Up to 6 months in lyophilized form at 0-5C. Molecular Formula: C9H14N4O5. AICAR is an analog of adenosine monophosphate (AMP) that is capable of stimulating AMP-dependent protein kinase . AICAR, an activator of AMPK, increased food intake, whereas compound C, an inhibitor of AMPK, decreased food intake. . These are organic compounds containing the imidazolecarboxamide linked to a ribose phosphate through a 1-2 bond. MOLECULAR FORMULA: C 9 H 15 N 4 O 8 P. PUBCHEM:CID 65110. AICA-Ribonucleotide (AICAR)[edit] AICAR (5-amino-1--D-ribofuranosyl-imidazole-4-carboxamide), also known as ZMP, is an analog of AMP that is capable of stimulating AMP-dependent protein kinase activity (AMPK). Storage instructions. Saline (control) is injected in volumes identical to those used for AICAR treatment in a manner identical to that of AICAR treatment. Monoisotopic Molecular Weight: 338.062749988: IUPAC Name {[(2R,3S,4R,5R)-5-(5-amino-4 . Aicar is a peptide which has the molecular formula C 9 H 15 N 4 O 8 P and molecular weight 338.211. 1 Promotes skeletal muscle autophagy via activation of FoxO3a. 577.08223818 Daltons. Store under desiccating conditions. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes. AICAR was found to activate AMP-activated protein kinase (AMPK) in skeletal muscle, i. AICAR 50mg 47.99 C9H17N4O9P 78357776 PubChem CID - 78357776 Synonyms - AICAR phosphate 681006-28- Molecular Weight - 356.23 Molecular Formula- C9H17N4O9P Add to cart Description Reviews (0) Description AICAR Peptide is an analogue of adenosine monophosphate (AMP) that is capable of stimulating AMP-dependent protein kinase (AMPK) activity. #P 0.05 versus 0.5 mM AICAR PDGF. Molecular Weight: 668.2 Chemical formula: C9H15N4O8P . The researchers gave the mice daily injections in their gut containing 50 mg Compound 14 per kg bodyweight. Store at -20C. Molecular Weight: 338.211. The human equivalent of this dose is about 300-500 mg. Other mice were given injections containing no active ingredients. AICAR is a cell-permeable adenosine analog that is a selective activator of AMP-activated protein kinase (AMPK) in adipocytes and hepatocytes. Chemsrc provides Acadesine(CAS#:2627-69-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Immortalized human HSC line hTERT and primary rat HSCs were stimulated with plateletderived growth factor (PDGF) with or without pretreatment with AMPK activator 5aminoimidazole4carboxamide14ribofuranoside (AICAR), metformin, or high molecular weight (HMW) adiponectin. Molecular Formula : C9H14N4O5 Molecular Weight : 258.23 GHS : Citations (2) PubMed Central . AMPK activation by AICAR or metformin inhibits HSC proliferation via suppression of ROS production and subsequent inhibition of AKT pathway. Lyophilized Powder. . AICAR / ATIC is a bifunctional protein that catalyzes the last two steps of the de novo purine biosynthetic pathway. A mutation in this gene results in AICA-ribosiduria. phosphoribulosylformimino-AICAR-phosphate. RECONSTITUTION: Required. Olanzapine (OLZ) is an antipsychotic drug used in the treatment of schizophrenia. Free shipping on inhibitor and protein orders over $500. Purity. Buy AICAR - an affordable, high quality CDK453 Inhibitor from Hello Bio, a trusted supplier for life science researchers worldwide Language. You must be a licensed and qualified healthcare practitioner. 27.99. Chemical Formula. Rated 5.00 out of 5 $ 36.99 - $ 45.99 $ 45.99 Add to cart . AICAR phosphate is an activator of AMP-activated protein kinase (AMPK). Store under desiccating conditions. AICAR regulates the glucose and lipid metabolism, and inhibits proinflammatory cytokines and iNOS production. Stability. Melting point : 214-215 C. . Molecular Weight: 338.21 g/mol. Body weight is measured prior to . . AMPK is a heterodimeric protein serine/threonine kinase that regulates the energy status of cells to protect cell from metabolic stress. Price Quantity; 45-A9978-5MG: 5 mg: $73.70 1/EA: . . 2 Controls smooth muscle cell hyperproliferation in vascular disease. It's a compound which has shown extremely impressive fat . Appearance: Off-White Powder . National Center for Biotechnology Information. . Targeting tumour proliferation with a small-molecule inhibitor of AICAR transformylase homodimerization Chembiochem. Research shows AICAR type Peptide will make you leaner and fitter without you doing any workouts and the effects are persistent. More, Size, This product can only be bought through Cayman Chemical. 3 Induces osteogenic differentiation in mesenchymal stem cells. DISCLAIMER: We do not supply peptides to Any individual under the age of 18. 00. . Select a batch to recalculate based on the batch molecular weight: 17513. AICAR improves ischemia or reperfusion injury and kidney fibrosis in rats. *The above data is based on the productmolecular weight 356.23. Store at -20C. . 2 In astrocyte-enriched glial cells, AICAR (1 mM) prevents increases in protein levels of inducible nitric oxide synthase (iNOS), COX-2, and manganese superoxide dismutase (MnSOD) induced by LPS and . AA Sequence: 5-Aminoimidazole-4-carboxamide ribonucleotide. It increases AMPK-dependent recruitment of ATP-sensitive K . National Library of Medicine. Download the HPLC Analysis/Mass Spectrum. Molecular Weight. The N-terminal domain has phosphoribosylaminoimidazolecarboxamide formyltransferase activity, and the C-terminal domain has IMP cyclohydrolase activity.
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